Mast cell activation and histamine can play a role in premenstrual syndrome (PMS) and premenstrual dysphoric disorder (PMDD).
That’s why mid-cycle, premenstrual, and perimenopausal mood symptoms can be relieved by antihistamines and natural histamine-reducing strategies such as vitamin B6, SAM-e, and a dairy-free diet.
Endometriosis is not a hormonal condition. It’s affected by estrogen but is not caused by estrogen or “estrogen dominance.”
Instead, endometriosis is a whole-body inflammatory and immune disease, and possibly a microbial disease.
What does that mean for treatment?
Progesterone is usually soothing to mood but can sometimes cause anxiety. A negative mood reaction to progesterone is called neurosteroid change sensitivity or premenstrual dysphoric disorder (PMDD) and affects about one in twenty women.
Here’s everything you need to know about progesterone and mood.
It’s time to bring progesterone into the conversation about women’s health. That’s according to Canadian endocrinology professor Jerilynn Prior in her paper “Women’s Reproductive System as Balanced Estradiol and Progesterone Actions—a revolutionary, paradigm-shifting concept in women’s health.” In the paper, Professor Prior makes the case that historically there has been a “cultural over-emphasis on estrogen” while “progesterone tends to be ignored or associated with negative effects.”
What is the difference between polycystic ovary syndrome (PCOS) and hypothalamic amenorrhea?
PCOS is the condition of androgen excess when all other causes of androgen excess have been ruled out. It can also cause irregular periods.
Hypothalamic amenorrhea (HA) is the loss of periods due to undereating. It can also present with mild acne, facial hair, and polycystic ovaries.