The Role of Histamine and Mast Cells in PMS and PMDD

mast cells histamine PMDDHere’s something important about PMS or PMDD (premenstrual dysphoric disorder): At least some of the time it’s caused or worsened by histamine or mast cell activation

Histamine can cause allergy-type symptoms such as hives and nasal congestion. Or it can cause anxiety, headaches, fatigue, brain fog, insomnia, and breast tenderness, the typical symptoms of PMS.

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Rescue Prescription for Menopause and Perimenopause

rescue for perimenopauseHere are the symptoms you don’t want to talk about: heavy, flooding periods; mood swings; insomnia; hot flushes.

It’s not fun to bleed through your clothes or wake at night with your heart pounding and your sheets all wet. And part of you is thinking that maybe you’ve done something wrong to get into this situation. Or, at the very least, that you’ve made the shameful mistake of getting older and entering perimenopause or “the M-word.”

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How to Survive the Great Progesterone Crash of Perimenopause

perimenopause and stressIn your forties, you may find you don’t cope as well with stress. It happens because losing progesterone during perimenopause can destabilize the HPA axis or stress response system.

This recalibration of the nervous system is why perimenopause is associated with an increased risk of anxiety, depression, and insomnia.

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What Estrogen Does in Your 40s (and How Progesterone Can Help)

Estrogen rollercoaster of perimenopause Hot flashes, sleep problems, mood swings, and crazy heavy periods. Is this menopause already? And you’re only 42? No, menopause may still be a decade away. This is perimenopause, which is the two to ten years of hormonal change before periods stop.

Perimenopause can be a tricky time and causes more symptoms than menopause itself. Conventional medicine has surprisingly little to offer. Your doctor will say you’re too young for hormone replacement, so she will likely prescribe the pill or an antidepressant, or tell you just to ride it out.

Read moreWhat Estrogen Does in Your 40s (and How Progesterone Can Help)

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