Mast cell activation and histamine can play a role in premenstrual syndrome (PMS) and premenstrual dysphoric disorder (PMDD).  That’s why mid-cycle, premenstrual, and perimenopausal mood symptoms can be relieved by antihistamines and natural histamine-reducing strategies such as quercetin, vitamin B6, SAM-e, and a dairy-free diet.  What are mast cells and histamine? Mast cells are immune … Continue reading The Role of Histamine and Mast Cells in PMS and PMDD