Mast cell activation and histamine can play a role in premenstrual syndrome (PMS) and premenstrual dysphoric disorder (PMDD).
That’s why both ovulatory and premenstrual mood symptoms can be relieved by over-the-counter antihistamines as well as natural histamine-reducing strategies such as vitamin B6, SAM-e, and a dairy-free diet.
Endometriosis is not a hormonal condition. It’s affected by estrogen but it’s not caused by estrogen or “estrogen dominance.”
Instead, endometriosis is a whole-body inflammatory and immune disease, and possibly a microbial disease.
What does that mean for treatment?
A menstrual cycle is, by definition, an ovulatory cycle in which ovulation is the main event and progesterone is made.
Any other kind of bleed is either the breakthrough bleed of an anovulatory cycle or a pill-bleed, which are not real menstrual cycles.
An ovulatory cycle has two phases.
Estrogen deficiency causes fatigue, weight gain, hair loss, depression, and insomnia. It also causes dry skin, recurrent bladder infections, and vaginal dryness.
Vaginal dryness is one of the most characteristic signs of estrogen deficiency and a good indicator that you do have deficiency.
Too much estrogen can cause heavy periods, breast pain, fibroids, and premenstrual irritability. It can also suppress thyroid function and increase the risk of breast cancer.
What natural treatment works to lower estrogen? To understand that, you need to think about the types of estrogen and why they’re high.