The Crucial Difference Between Progesterone and Progestins

progesterone versus progestinProgestins such as drospirenone, levonorgestrel, or medroxyprogesterone are not progesterone.

That’s because progesterone is not a generic term like estrogen. Instead, progesterone refers only to the hormone made by the corpus luteum or taken as oral micronized progesterone.

Consider the structural difference between progesterone and the progestin drug levonorgestrel, which is used in many oral contraceptives, implants, hormonal IUDs, and the morning-after pill.

Progestin or levonorgestrel versus progesterone

Can you spot the difference?

Levonorgestrel is actually more similar to testosterone than it is to progesterone, which is why it can cause hair loss and weight gain.

Levonorgestrel has a high androgen index and is similar to testosterone.

Progesterone versus progestins

There are several other differences between real (body-identical) progesterone and progestins.

ProgesteroneProgestins
improves cardiovascular healthcan cause high blood pressure
stimulates hair growth can cause hair loss
has anti-androgen properties can be androgenic or “testosterone-like”
generally good for mood and sleep can cause anxiety and depression
may reduce the risk of breast cancerincrease the risk of breast cancer

Are you still confused about progesterone versus progestin? Think of it this way: Progestin and progesterone have the same beneficial thinning effect on the uterine lining but almost opposite effects in every other part of the body including the breasts and brain.

In general, real progesterone has the advantage of being safer for breasts and usually better for mood.

How to get progesterone

There’s no progesterone in hormonal birth control.

The only way to get real, natural progesterone is to:

  • Make it yourself. Read Roadmap to progesterone and Period Repair Manual.
  • Take oral micronized progesterone capsules (natural progesterone). Bioidentical or body-identical progesterone is actual progesterone (like the molecule above)—not levonorgestrel or another progestin. Progesterone is available as natural progesterone cream, compounded progesterone capsules, or products such as Prometrium, Utrogestan, Famenita, or Teva.

Check your label and consult the chart in my bioidentical hormone therapy post. Also, see my podcast/YouTube video about body-identical hormone therapy.

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