Troubleshooting Progesterone

A practical guide to making progesterone therapy work for you.

Progesterone is a fascinating hormone. It’s calming, protective, metabolically active, and deeply responsive to its environment, especially estrogen and the nervous system. In the right context, it can be transformative for sleep, mood, heavy bleeding, and perimenopausal symptoms. In a not-quite-right context (for example, very high estrogen or inflammation), progesterone can feel strange or uncomfortable, especially at first. 

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Why Progesterone Is Both Good and Bad for Mood—and How to Treat PMDD

Progesterone is usually good for mood, but can cause sometimes cause anxiety.

When it comes to mood, progesterone is a paradox.

For most women, it’s soothing, thanks to its calming effect on the brain. But for some, it can trigger anxiety, irritability, or even rage. What’s going on?

💡 Also read: Troubleshooting progesterone and Top 6 natural treatments for premenstrual mood symptoms

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High Histamine Can Make for a Tougher Perimenopause

A tendency to allergies or high histamine can contribute to perimenopausal symptoms like night sweats, anxiety, sleep disturbance, fluid retention, breast pain, migraines, and heavy menstrual bleeding.

That’s because histamine increases with estrogen, and estrogen is usually higher than normal during the early years of perimenopause.

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Guide to Natural Progesterone

How to use natural progesterone.

Body-identical progesterone (also called bioidentical, natural, or oral micronized progesterone) can be an effective treatment for a range of women’s health conditions, including PCOS, PMDD, migraines, endometriosis, adenomyosis, and perimenopause.

To be clear: progesterone is a real hormone (identical to what the body makes) and usually requires a doctor’s prescription. Depending on your country, brand names include Prometrium, Utrogestan, Teva, and Famenita. In some countries, progesterone cream is available over the counter. Cream can help with mild symptoms, but it’s generally less effective than capsules.

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