Help for Hormonal Sleep Problems

Hormonal sleep problems.

Can’t sleep? It could be your hormones.

Sleep disturbance is common during the premenstrual phase of the menstrual cycle and is usually the result of dropping progesterone or a histamine or mast cell reaction.

Sleep disturbance can also occur during perimenopause and menopause. 

Hormonal sleep problems


Premenstrual sleep problems are caused by one or more of the following:


Perimenopausal sleep problems are caused by losing progesterone which results in a recalibration of the brain and stress response system. Perimenopause can also be a time of mast cell activation or high histamine, which further worsens sleep.


Menopausal sleep problems are caused by losing both progesterone and estrogen which results in changes to the part of the brain that controls circadian rhythm. Losing estrogen can cause sleep maintenance insomnia, which means waking at 2 or 3 am. Fortunately, the brain can adapt to low estrogen, and sleep usually returns to normal.

Sleep solutions

Start with the usual sleep-enhancing techniques of exercise, morning light, and sleeping in a dark room.

You may then want to try one or more of the nutritional supplements that calm GABA receptors in the brain. They include magnesium, taurine, vitamin B6, and the amino acid glycine.

👉 A dose of 3 grams of glycine at bedtime is a safe and effective sleep remedy.

If you suffer headaches or other signs of mast cell activation or high histamine, lowering histamine could be the key to restoring healthy sleep.

Finally, consider hormone treatment. Body-identical progesterone capsules work best for premenstrual or perimenopausal sleep problems, but a combination of progesterone and estrogen may be needed for the mid-sleep waking typical of menopause. It might also help to know that mid-sleep waking is normal.

Menopause and premenstrual sleep problems.
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