Why Progesterone Is Both Good and Bad for Mood—and How to Treat PMDD

Progesterone is usually good for mood, but can cause sometimes cause anxiety.

When it comes to mood, progesterone is a paradox.

For most women, it’s soothing, thanks to its calming effect on the brain. But for some, it can trigger anxiety, irritability, or even rage. What’s going on?

💡 Also read: Troubleshooting progesterone and Top 6 natural treatments for premenstrual mood symptoms

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Taurine: 5 Benefits for Women’s Health

Taurine for women's health

Taurine is one of my favorite prescriptions for perimenopause, menopause, sleep, mood, insulin resistance, and migraine prevention.

Taurine is an amino acid, but unlike most amino acids, it doesn’t build protein. Instead, taurine has directly beneficial effects on the liver, brain, mitochondria, immune system, and nervous system. Taurine is so important that it makes up about 0.1 percent of total body weight.

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Roadmap to Progesterone

how to make progesterone

Progesterone is beneficial because it lightens periods. It also reduces inflammation, regulates immune function, and supports healthy thyroid, brain, bones, and breasts.

Do you make enough progesterone? Are you sure?

The only way to make progesterone is to ovulate and have a healthy luteal phase.

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The Role of Histamine and Mast Cells in PMS and PMDD

Histamine and premenstrual mood symptoms.

Mast cell activation and histamine can play a role in premenstrual syndrome (PMS) and premenstrual dysphoric disorder (PMDD). 

That’s why mid-cycle, premenstrual, and perimenopausal mood symptoms can be relieved by antihistamines and natural histamine-reducing strategies such as quercetin, vitamin B6, SAM-e, and a dairy-free diet. 

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