The Role of Histamine and Mast Cells in PMS and PMDD

histamine and PMDD

Mast cell activation and histamine can play a role in premenstrual syndrome (PMS) and premenstrual dysphoric disorder (PMDD). 

That’s why both ovulatory and premenstrual mood symptoms can be relieved by over-the-counter antihistamines as well as natural histamine-reducing strategies such as vitamin B6, SAM-e, and a dairy-free diet. 

Read moreThe Role of Histamine and Mast Cells in PMS and PMDD

How Vitamin B6 Relieves Premenstrual Mood Symptoms

PMS cureThank you to my nutrition professor who first taught me about vitamin B6 (pyridoxine) for PMS. It is a reliable treatment for premenstrual mood problems including PMDD.

I still remember B6 as the eureka moment in how I thought about periods. Suddenly, I had much higher expectations of what a period should be like. Premenstrual mood symptoms are common, but they’re not normal. 

Read moreHow Vitamin B6 Relieves Premenstrual Mood Symptoms

Help for Hormonal Sleep Problems

Premenstrual sleep problems are caused by either a drop in progesterone, sensitivity to progesterone, or a histamine or mast cell reaction.

Sleep problems are also a common feature of perimenopause and menopause. 

Read moreHelp for Hormonal Sleep Problems

Why Progesterone Is Both Good and Bad for Mood (and How to Treat PMDD)

mood effects of progesteroneIs progesterone good or bad for mood? Progesterone calms the brain and promotes sleep. At the same time, it does play a role in the mood symptoms of premenstrual dysphoric disorder (PMDD).

How can both things be true? The short answer is that progesterone is usually good for mood but can sometimes be bad.

Keep reading for the longer answer about progesterone and mood.

Read moreWhy Progesterone Is Both Good and Bad for Mood (and How to Treat PMDD)

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