Why Progesterone Is Both Good and Bad for Mood (and How to Treat PMDD)

Mood effects of progesterone.

Progesterone is usually soothing to mood but can sometimes cause anxiety.

A negative mood reaction to progesterone is called neurosteroid change sensitivity or premenstrual dysphoric disorder (PMDD) and affects about one in twenty women.

Here’s everything you need to know about progesterone and mood.

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The Curious Link Between Estrogen, Mast Cells, and Histamine

The role of mast cells and histamine in estrogen dominanceHeadaches. Anxiety. Insomnia. Brain fog. Hives. Nasal congestion. These are just a few of the symptoms of mast cell activation or high histamine.

Histamine symptoms are more common in women and often track with the menstrual cycle, occurring when estrogen is high at ovulation and then again just before the period. 

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How Vitamin B6 Relieves Premenstrual Mood Symptoms

PMS cure

Thank you to my nutrition professor, who first taught me about vitamin B6 (pyridoxine or pyridoxal-5-phosphate) for PMS. It is an effective, reliable treatment for premenstrual mood problems, including PMDD.

Back then (30 years ago), vitamin B6 relieved my own premenstrual symptoms so dramatically that it became my eureka moment in natural health and menstrual health. I realized that although premenstrual mood symptoms are common, they’re not normal. And going forward, I had much higher expectations of what a period should be like. 

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