Why Progesterone Is Both Good and Bad for Mood—and How to Treat PMDD

Progesterone is usually good for mood, but can cause sometimes cause anxiety.

When it comes to mood, progesterone is a paradox.

For most women, it’s soothing, thanks to its calming effect on the brain. But for some, it can trigger anxiety, irritability, or even rage. What’s going on?

💡 Also read: Troubleshooting progesterone and Top 6 natural treatments for premenstrual mood symptoms

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Natural Treatment of Hormonal Migraines

menstrual migraines

According to a Lancet review, migraines tend to occur during the premenstrual phase due to prostaglandins, histamine, and the steep decline in estrogen (aka “estrogen withdrawal”) leading up to the period.

Body-identical progesterone can shelter the brain from that estrogen withdrawal and reduce the frequency and intensity of menstrual migraines.

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Natural Treatment of Heavy Periods

Natural treatment of heavy periods.

In a normal period, you should not lose more than about 80 mL of menstrual fluid over all the days of the bleed. That’s equivalent to about five tablespoons spread over all the days of the bleed.

In episode two of my podcast/YouTube video, I discuss heavy periods including the role of hormone imbalance, mast cell activation, and insulin resistance; simple period-lightening strategies such as iron, zinc, and a dairy-free diet; and using body-identical progesterone to lighten periods.

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How to Improve Premenstrual Mood Symptoms (A Summary of Natural Treatments)

natural treatment for premenstrual mood

There’s a lot more to treating premenstrual mood symptoms than just the pill or SSRI antidepressants. Alternative strategies for premenstrual syndrome (PMS) and premenstrual dysphoric disorder (PMDD) include iodine, magnesium, vitamin B6, vitex (chaste tree), progesterone, and a natural antihistamine approach.

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