Why Progesterone Is Both Good and Bad for Mood—and How to Treat PMDD

Progesterone is usually good for mood, but can cause sometimes cause anxiety.

When it comes to mood, progesterone is a paradox.

For most women, it’s soothing, thanks to its calming effect on the brain. But for some, it can trigger anxiety, irritability, or even rage. What’s going on?

💡 Also read: Troubleshooting progesterone and Top 6 natural treatments for premenstrual mood symptoms

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High Histamine Can Make for a Tougher Perimenopause

A tendency to allergies or high histamine can contribute to perimenopausal symptoms like night sweats, anxiety, sleep disturbance, fluid retention, breast pain, migraines, and heavy menstrual bleeding.

That’s because histamine increases with estrogen, and estrogen is usually higher than normal during the early years of perimenopause.

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Natural Treatment of Hormonal Migraines

menstrual migraines

According to a Lancet review, migraines tend to occur during the premenstrual phase due to prostaglandins, histamine, and the steep decline in estrogen (aka “estrogen withdrawal”) leading up to the period.

Body-identical progesterone can shelter the brain from that estrogen withdrawal and reduce the frequency and intensity of menstrual migraines.

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What’s the Story With Dairy and Period Problems?

Dairy can cause period problems.

For some women, stopping normal dairy products can relieve period symptoms. But why?

In the latest episode of my podcast and YouTube video, I discuss the inflammatory effects of A1 casein and how a mast cell histamine response can drive period problems such as premenstrual mood symptoms, heavy bleeding, and pain.

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