The Curious Link Between Estrogen, Mast Cells, and Histamine

The role of mast cells and histamine in estrogen dominanceHeadaches. Anxiety. Insomnia. Brain fog. Hives. Nasal congestion. These are just a few of the symptoms of mast cell activation or high histamine.

Histamine symptoms are more common in women and often track with the menstrual cycle, occurring when estrogen is high at ovulation and then again just before the period. 

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Why Progesterone Is Both Good and Bad for Mood (and How to Treat PMDD)

Mood effects of progesterone.Progesterone is usually soothing to mood but can sometimes cause anxiety. A negative mood reaction to progesterone is called neurosteroid change sensitivity or premenstrual dysphoric disorder (PMDD) and affects about one in twenty women.

Here’s everything you need to know about progesterone and mood.

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How to Survive the Great Progesterone Crash of Perimenopause

perimenopause and stressIn your forties, you may find you don’t cope as well with stress. It happens because losing progesterone during perimenopause can destabilize the HPA (adrenal) axis or stress response system.

This recalibration of the nervous system is why perimenopause is associated with an increased risk of anxiety, depression, and insomnia.

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Ovulation Is the Main Event of the Menstrual Cycle

Anovulatory cycles and pill bleeds.A menstrual cycle is, by definition, an ovulatory cycle in which ovulation is the main event and progesterone is made.

Any other kind of bleed is either the breakthrough bleed of an anovulatory cycle or a pill-bleed, which are not real menstrual cycles. 

An ovulatory menstrual cycle consists of a follicular phase and a luteal phase.

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